Protein-Bound 4-Hydroxy-2-Nonenal as a Marker of Oxidative Stress
نویسندگان
چکیده
منابع مشابه
A study on ceftriaxone-induced lipid peroxidation using 4-hydroxy-2-nonenal as model marker.
4-Hydroxy-2-nonenal, an indicator of lipid peroxidation process. was used as model marker to explore ceftriaxone-induced lipid peroxidation in goat liver homogenate. Ceftriaxone was found to induce lipid peroxidation significantly. It was further found that ascorbic acid could significantly arrest ceftriaxone-induced lipid peroxidation. The results corroborate the earlier findings with malondia...
متن کامل1 4 - hydroxy - 2 - nonenal : a critical target in oxidative stress ? 1
20 In this perspective, we summarize and discuss critical advancements in the study of 421 hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or 22 exacerbated by oxidative stress. Since its identification in 1980, 4-HNE has been extensively 23 studied with an emphasis on its formation, its role in pathology, and its targets. As a reactive 24 aldehyde, ...
متن کاملProtein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids.
In the present study, to investigate the contribution of n-3 PUFAs in the oxidative modification of protein in vivo, we characterize the covalent binding of 4-hydroxy-2-hexenal (HHE), a potent cytotoxic aldehyde originating from the peroxidation of n-3 PUFAs, to protein and describe the production of this aldehyde in oxidatively modified LDL and in human atherosclerotic lesions. Upon incubation...
متن کامل4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules.
Oxidative stress is associated with important pathophysiological events in a variety of diseases. It has been postulated that free radicals and lipid peroxidation products generated during the process may be responsible for these effects because of their ability to damage cellular components such as membranes, proteins, and DNA. In the present study, we provide evidence that oxidative stress ca...
متن کاملl,A^-Ethenodeoxyguanosine as a Potential Marker for DNA Adduci Formation by fra/is-4-Hydroxy-2-nonenal!
The reaction of rraiu-4-hydroxy-2-nonenaL,a major a,/}-unsaturated aldehyde released during lipid peroxidation, with deoxyguanosine under physiological conditions was investigated in order to assess its DNA damaging potential. This aldehyde was dissolved in tetrahydrofuran (THF) prior to addition to the reaction mixture. The results showed that structurally different adducts were formed in thes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition
سال: 2005
ISSN: 0912-0009,1880-5086
DOI: 10.3164/jcbn.36.1